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Amino Acids Overview

Peptide Bond

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Solid Phase Peptide Synthesis

Protecting Groups for SPPS

Application of Synthetic Peptides

Peptide Glossary

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Welcome to Peptide Guide!

Peptide is a molecule formed by joining two or more amino acids. When the number of amino acids is less than about 50 these molecules are named peptides while larger sequences are referred to as proteins.

The amino acids are coupled by a peptide bond, a special linkage in which the nitrogen atom of one amino acid binds to the carboxyl carbon atom of another.

Peptides (proteins) are present in every living cell and possess a variety of biochemical activities. They appear as enzymes, hormones, antibiotics, receptors, etc.

Synthetic peptides may be useful in structure-function studies of polypeptides, as peptide hormones and hormone analogues, in the preparation of cross-reacting antibodies, and in the design of novel enzymes.

Peptides are synthesized by coupling the carboxyl group or C-terminus of one amino acid to the amino group or N-terminus of another. There are two strategies for peptide synthesis: liquid-phase peptide synthesis and solid-phase peptide synthesis (SPPS).

The goal of this project is to collect all information about peptides and peptide synthesis in one place.